KCE-17007: Vergleichende Studie zwischen topischer und systemischer Behandlung von lokalisierten neuropathischen Schmerzen - PELICAN-Studie

Trial Description

Title	Safety, efficacy and patient acceptability of topical treatment versus systemic treatment: a randomized, multicenter, comparative pragmatic trial in adult patients suffering from diverse localized neuropathic pain (LNP) syndromes. PELICAN (PrEgabalinLIdocaineCApsaicinNeuropathicpain) - KCE-17007
Participants (P)	Adult patients suffering from localized neuropathic pain (LNP) across a wide variety of etiologies, with a duration between 1 and 12 months (subacute to chronic neuropathic pain conditions).
Intervention (I)	Topical treatment 1: lidocaine 5% medicated plaster (Versatis)Topical treatment 2: capsaicin 8% patch (Qutenza)
Control (C)	Systemic treatment: pregabalin (Lyrica)
Outcome (O)	The primary outcome is the change in quality of life for the patient, measured by EQ-5D-5L from baseline to 6 weeks.
Trial Design	Multicenter three arm 1:1:1 randomized, open-label comparative trial.
Sample Size	591
Trial duration	27 months
Budget	€M2.83 (incl. VAT)
Status	Open to recruitment