What is the KCE Trials programme?

KCE Trials is a programme of publicly funded, non-commercial, practice-oriented clinical trials. These studies address questions that are generally not studied by industry, despite their high social importance. For example, few studies compare two surgical techniques, or investigate the effect of already existing drugs in groups that are under-represented in commercial studies, such as children or the elderly.

KCE Trials is responsible for the selection, financing and follow-up of the studies, but the studies themselves are carried out in the participating Belgian hospitals. KCE Trials regularly launches calls for study proposals (Calls) and selects the projects that are most likely to improve clinical practice in Belgium (for more information about this selection, see here). KCE Trials mainly focuses on comparative studies. Projects on development and innovation and preclinical studies are not selected.

The clinical studies of KCE Trials:

  • non-commercial
  • practice-oriented and focused on current standards of care: unlike commercial trials, these involve patients treated under real-life conditions (in hospitals, in the community and in nursing homes, etc…)
  • comparative: they compare the efficacy of treatments which have already been used but which have never been directly compared to one another
  • potentially able to lead to cost savings for health insurance
  • not limited to drugs or medical devices: they can also involve lifestyle modifications, psychotherapies, diagnostic tests, surgical interventions, etc.
  • guaranteed to generate databases that are made available for public interest research, for example to conduct detailed and independent cost-effectiveness studies.

The working language of KCE Trials is English. This ensures more efficiency in international cooperation. For all communications, publications and activities English is used.

If you wish to be kept informed about the activities of KCE Trials and the Calls, please register here.

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