Clinical trials in the analysis phase
- AGNOHSTIC: HYALOBARRIER® GEL ENDO versus no HYALOBARRIER® GEL ENDO following operative hysteroscopy for improving reproductive outcome in women with intrauterine pathology wishing to become pregnant (KCE-17002)
- BLENDED: Blended Care Psychodynamic Therapy or Cognitive Behavioral Therapy versus Face-to-Face Psychotherapy for Depression: A pragmatic multicentre randomized controlled non-inferiority trial (KCE-17003)
- RECOVER@HOME: Recovery from disability after geriatric-home rehabilitation versus standard of care: a pilot trial in older patients with disability at hospital discharge (KCE-221383)
- RenoMet: Metformin as RenoProtector in Non-Diabetic Patients with Progressive Chronic Kidney Disease (CKD stages 2, 3A and 3B): a multi-centre, practice-oriented, repurposing, double-blind, placebo-controlled, randomized clinical trial (KCE-17006)
Clinical trials which have finished recruiting
- BE-Quilt: Comparison of ‘quilting sutures’ with ‘conventional’ sutures and drain placement’ after mastectomy: a multicentre, pragmatic randomised controlled trial (KCE-221361)
- BEST CORNEA: A randomised multicentric parallel group pragmatic trial of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK) in corneal endothelial decompensation (KCE-201254)
- CASES: Carotid Artery Stenting during Endovascular treatment of acute ischemic Stroke versus deferred treatment of carotid artery stenosis (BeNeFIT21561)
- HYFOIL: Impact on fertility after additional tubal flushing with oil-based contrast versus no additional flushing: a randomised, multicentre, pragmatic trial in infertile women with at least one patent tube at HyFoSy (KCE-191224)
- PEPPER: Determining the optimal strategy for stopping chronic proton pump inhibitor therapy in primary care patients: impact of on-demand use, adjunctive therapies and antacids (KCE-201277)
- TreatPaCS: Treatment for preschool age children who stutter: a randomised, multicentre, non-inferiority parallel group pragmatic trial with Mini-KIDS, social cognitive behaviour treatment and the Lidcombe Program (KCE-201257)
Clinical trials open to recruitment
- ALLTogether1: A trial for children and young adults with acute lymphoblastic leukaemia (ALL) (KCE-17010)
- AWARE: Elective Adhesiolysis vs. wait-and-see policy to prevent recurrence of adhesive small bowel obstruction (aSBO)(BeNeFIT-22025)
- BELGICA: achieving a BEtter outcome through Limiting the GlIoblastoma Clinical tArget volume (KCE-231426)
- BONANZA: a randomised controlled trial that is testing whether a management strategy guided by early brain tissue oxygen monitoring in patients in with severe traumatic brain injury improves long term neurological and functional outcomes (KCE-211323)
- COGENIUS: Comparison of conventional and cooled radiofrequency treatment of the genicular nerves versus sham procedure for patients with chronic knee pain: a multicentre, double blind, randomised controlled trial (KCE-201255)
- COL BE PCI: COLchicine in BElgium in patients with coronary artery disease after Percutaneous Coronary Intervention (KCE-211324)
- DIRECT TMS: The enhancing effect of dual interventions versus conventional TMS in the treatment of depression (BeNeFIT22018)
- DRAGON: An international multicentre randomised controlled trial to compare combined Portal and Hepatic Vein Embolisation (PVE/HVE) with PVE alone in patients with primary liver cancers (BeNeFIT220028)
- ENDO REAL - Reproductive outcomes with letrozole co-treatment during ovarian stimulation in women with endometriosis undergoing IVF/ICSI: a randomised, multicentre, parallel group pragmatic trial (KCE-241520)
- EPO-TRAUMA: ErythroPOietin alfa to prevent mortality and reduce severe disability in critically ill TRAUMA patients: a multi-centre, stratified, double-blind, randomised, placebo-controlled trial (KCE-221359)
- GPS-AD - General practitioner & pharmacist support for discontinuing long-term antidepressants in clinically stable patients: a cluster randomised pragmatic trial in primary care (KCE-241543)
- HELIOS: Proactive therapeutic drug monitoring versus routine care with the novel biologics in psoriasis : a pragmatic, multicentric, randomised, controlled study (KCE-221375)
- HIT HARD: A pHase III cluster randomIsed controlled, cross-over, non-inferiority Trial of a short course, High dose AntimicRobials vs conventional dose and Duration in critically ill patients (BeNeFIT-220010)
- HOT-NSTI: Adjunctive Hyperbaric Oxygen Treatment for Patients with Necrotizing Soft-Tissue Infection (KCE-241539)
- IN-SPIRED: a randomised, multicentre clinical trial investigating home-based inspiratory muscle training compared to usual care on readmission rate after a severe acute exacerbation of chronic obstructive pulmonary disease (KCE-231479)
- IODA: A pragmatic, randomized trial that compares Immediate versus Optional Delayed surgical repair for treatment of acute anterior cruciate ligament injury (KCE-181158)
- IRON-PH: a randomized, double-blind, placebo-controlled, multicentre trial, assessing the impact of ferric carboxymaltose on exercise capacity and functional status in pulmonary hypertension (KCE-241530)
- ITB vs SDR: Intrathecal baclofen pump versus selective dorsal rhizotomy for non-ambulatory children with cerebral palsy (BeNeFIT2210024)
- LIFETWIN: lifestyle intervention to improve twin pregnancy outcome: a multicentric randomized control trial - Pilot (KCE-231468)
- Opt-Pembro: OPTimizing adjuvant prescription of PEMBROlizumab in patients with early-stage triple-negative breast cancer achieving pathologic complete response (KCE-231465)
- OSI-SAVE: Increasing the dosing interval of osimertinib in patients with EGFR mutated locally advanced or metastatic non-small cell lung cancer (KCE-241540)
- PERSuaDER: PERi-operative Selective Decontamination of the Digestive tract to prevent severe infectious complications after Esophagectomy (BeNeFIT21563)
- PRECISe-2: A randomised controlled, multicentre trial investigating the impact of low versus standard enteral protein provision on health-related quality of life following intensive care admission (KCE-241531)
- PRIMALung: PRophylactic cerebral Irradiation or active MAgnetic resonance imaging surveillance in small-cell Lung cancer patients (KCE-211330)
- PRIORI: Synbiotics in Patients at RIsk fOr preterm birth: a multi-center double-blind Randomized placebo-controlled trial (KCE-201273)
- PULSE: Maintenance Pembrolizumab at Usual or Low doSE in non-squamous lung cancer: a non-inferiority study (KCE-231395)
- R³: An evidence-based Rehabilitation pathway for patients undergoing surgery for lumbar Radicular pain to promote Return to work: a cluster randomized trial comparison with usual care (KCE-231473)
- REPAIR study: Rebuilding Parent young Adult Interpersonal Relationships (BeNeFIT21573)
- SAUNA: Continuing Somatostatin Analogues Upon progression in Neuroendocrine tumour pAtients (BeNeFIT21577)
- SHAPERS: Efficacy and safety of short-course radiotherapy (SCRT) versus total neoadjuvant therapy in older patients with locally advanced rectal cancer: a multicentre, open-label, randomised pragmatic clinical trial (KCE-211331)
- SOPRANO: Prevention of postoperative endoscopic disease recurrence in Crohn's disease (KCE-201262)
- SurLym: Comparison of reconstructive surgery versus no surgery, additional to decongestive lymphatic therapy (usual care), for the treatment of lymphoedema, through a multicentre, pragmatic randomised controlled trial (KCE-191245)
- TELSTAR-2: Evaluation of treatment with anti-seizure medication in comatose cardiac arrest patients with status epilepticus on continuous electroencephalographic (BeNeFIT-221002)
Clinical trials starting soon
- BRAVE: Same admission cholecystectomy vs initial conservative management in patients with acute cholecystitis and > 5 days of symptoms: a multicentre randomised controlled trial (BeNeFIT24012)
- Clear Ear: ChoLEsteatomA Recidivism – Evaluation And Recommendations (BeNeFIT24031)
- DoPeNS: A randomised, multicentre, non-inferiority study of oral Doxycycline versus intravenous Penicillin for the treatment of NeuroSyphilis (BeNeFIT24010)
- HIPRO: Standard-dose versus high-dose prophylactic anticoagulation in critically ill medical patients at risk for thromboprophylaxis failure: a multicentre, double-blind, randomized controlled trial (KCE-241518)
Clinical Trials abandoned or stopped before completion
- DAWN-antivirals: The DAWN antivirals trial for ambulatory COVID-19 patients (COV201279)
- DUET: Azole-echinocandin combination therapy for invasive aspergillosis. A randomized pragmatic superiority trial (BeNeFIT18558)
- Foot Drop: A prospective, multi-center, randomized, parallel-group controlled trial to compare conservative versus surgical treatment of foot drop in peroneal nerve entrapment (KCE-191232)
- KIWI: Bronchodilators for wheeze in young children presenting to primary care: a randomised, placebo-controlled, multicentre, parallel group trial (BeNeFIT18554)
- PELICAN: Localized neuropathic pain: a study to compare topical treatment versus systemic treatment (KCE-17007)
- RESET ASDH: Randomized Evaluation of Surgery in Elderly with Traumatic Acute SubDural Hematoma (BeNeFIT18565)
Recruitment in KCE Trials funded studies - dynamic dashboards
Click here to access the dynamic dashboards on recruitment status of studies funded by KCE Trials Programme in Belgian hospitals.
These dashboards are updated every Friday, based on the data entered in SmartSimple by Project Managers of the funded studies.
You can find the guide for Project Managers 'How to update recruitment data in SmartSimple' here.
