ARON: Auswirkungen von klinischer Beratung und

TRIAL DESCRIPTION

Title	Impact of a diagnostic algorithm including clinically guided point-of-care C-reactive protein testing and safety netting advice on antibiotic prescribing rate and further management of acutely ill children presenting to ambulatory care: multicentre, cluster-randomized, parallel group pragmatic trial
Participants (P)	Children aged 6 months to 12 years of age with an acute illness episode presenting to in-hours general practice or out-of-hospital community paediatrics offices
Intervention (I)	Diagnostic algorithm including a point of care CRP test
Control (C)	Diagnosis and Treatment/Management as per usual care
Outcome (O)	Antibiotic prescribing rate at index consultation
Trial Design	Multicentre, cluster-randomized, parallel group pragmatic trial
Sample Size	122 GPs including 6111 children
Trial duration	33 months from FPI to CSR
Budget	€2,980,000

TRIAL TEAM

Sponsor	UZ Leuven
Chief Investigator	Prof Dr Jan Y Verbakel
Participating Investigators	Academic centres for general practice of KU Leuven, U Liege, U Gent, VUB, U Antwerp, UC Louvain
Lead Dutch speaking GPs	Prof Dr An De Sutter
Lead French speaking GPs	Dr Louise Joly
External partner	Abbott Rapid Diagnostics BV